it's been a while since I was experimenting with the I2C port. I'm building the hardware to mount my electronics on (an old tractor with a newer Mercedes engine for tractorpulling).
I haven't used resistors until now, but I hooked up about 6 or so Arduino Nano clones. Requesting around 24+ variables in total for 50 to a 100 times a second. The only thing I experienced was that every X request was a bit slower, total transfertime was 10 to 20% longer. I'm designing the PCB's which have room for resistors. When the pcb's are ready I put the scope on and see what if I can make it better. But still a lot of work.